Abstract
3-Hydroxypropionic acid (3-HP) is a valuable platform chemical that can be produced biologically from glucose or glycerol. This review article provides an overview and the current status of microbial 3-HP production. The constraints of microbial 3-HP production and possible solutions are also described. Finally, future prospects of biological 3-HP production are discussed.
Keywords:
3-Hydroxypropionic acid; Aldehyde dehydrogenase; Coenzyme/vitamin B(12); Glycerol; Glycerol dehydratase; Klebsiella pneumoniae.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aldehyde Dehydrogenase / blood*
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Aldehyde Dehydrogenase / chemistry
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Aldehyde Dehydrogenase / metabolism
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Fermentation / genetics*
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Glucose / chemistry*
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Glycerol / chemistry*
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Humans
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Hydro-Lyases / chemistry
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Hydro-Lyases / metabolism
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Klebsiella pneumoniae / genetics
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Klebsiella pneumoniae / metabolism
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Lactic Acid / analogs & derivatives*
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Lactic Acid / biosynthesis
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Propylene Glycols
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Recombination, Genetic
Substances
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Propylene Glycols
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Lactic Acid
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hydracrylic acid
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Aldehyde Dehydrogenase
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Hydro-Lyases
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glycerol dehydratase
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Glucose
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Glycerol