Recent advances in biological production of 3-hydroxypropionic acid

Biotechnol Adv. 2013 Nov;31(6):945-61. doi: 10.1016/j.biotechadv.2013.02.008. Epub 2013 Mar 6.

Abstract

3-Hydroxypropionic acid (3-HP) is a valuable platform chemical that can be produced biologically from glucose or glycerol. This review article provides an overview and the current status of microbial 3-HP production. The constraints of microbial 3-HP production and possible solutions are also described. Finally, future prospects of biological 3-HP production are discussed.

Keywords: 3-Hydroxypropionic acid; Aldehyde dehydrogenase; Coenzyme/vitamin B(12); Glycerol; Glycerol dehydratase; Klebsiella pneumoniae.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aldehyde Dehydrogenase / blood*
  • Aldehyde Dehydrogenase / chemistry
  • Aldehyde Dehydrogenase / metabolism
  • Fermentation / genetics*
  • Glucose / chemistry*
  • Glycerol / chemistry*
  • Humans
  • Hydro-Lyases / chemistry
  • Hydro-Lyases / metabolism
  • Klebsiella pneumoniae / genetics
  • Klebsiella pneumoniae / metabolism
  • Lactic Acid / analogs & derivatives*
  • Lactic Acid / biosynthesis
  • Propylene Glycols
  • Recombination, Genetic

Substances

  • Propylene Glycols
  • Lactic Acid
  • hydracrylic acid
  • Aldehyde Dehydrogenase
  • Hydro-Lyases
  • glycerol dehydratase
  • Glucose
  • Glycerol