Septic shock after seasonal influenza vaccination in an HIV-infected patient during treatment with etanercept for rheumatoid arthritis: a case report

Clin Vaccine Immunol. 2013 May;20(5):761-4. doi: 10.1128/CVI.00081-13. Epub 2013 Mar 6.

Abstract

Anti-tumor necrosis factor alpha (anti-TNF-α) is used in the treatment of rheumatic diseases not responsive to first-line regimens. Data on the safety of anti-TNF-α in HIV-infected patients are scarce and conflicting. We describe a case of septic shock and multiorgan failure that occurred after etanercept initiation and influenza vaccination in an HIV-infected woman with rheumatoid arthritis.

Publication types

  • Case Reports

MeSH terms

  • Antiretroviral Therapy, Highly Active
  • Antirheumatic Agents / therapeutic use*
  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / drug therapy*
  • Etanercept
  • Female
  • HIV Infections / complications*
  • HIV Infections / drug therapy
  • Humans
  • Immunoglobulin G / adverse effects*
  • Immunoglobulin G / therapeutic use
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / therapeutic use
  • Influenza Vaccines / administration & dosage
  • Influenza Vaccines / adverse effects*
  • Influenza Vaccines / immunology
  • Middle Aged
  • Multiple Organ Failure / etiology
  • Receptors, Tumor Necrosis Factor / therapeutic use
  • Shock, Septic / etiology*
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Vaccination

Substances

  • Antirheumatic Agents
  • Immunoglobulin G
  • Immunosuppressive Agents
  • Influenza Vaccines
  • Receptors, Tumor Necrosis Factor
  • Tumor Necrosis Factor-alpha
  • Etanercept