Synthesis of Substituted Isatins

Tetrahedron Lett. 2013 Feb 1;54(8):1008-1011. doi: 10.1016/j.tetlet.2012.12.035. Epub 2012 Dec 21.

Abstract

Isatins are valuable intermediates for heterocyclic chemistry. Most of the common methods for their production are less than adequate when the number and lipophilicity of substituents on the targeted isatin are increased. Our group desired such molecules and identified an alternative method for their production.

Keywords: Sandmeyer isatin synthesis; isatin; oximinoacetanilides.