A catalyst-free, one-pot three-component aminomethylation of α-substituted nitroacetates: theoretical and experimental studies into the rate-accelerating effects of the solvent methanol

Cong-Bin Ji; Zhong-Yan Cao; Xin Wang; De-Yin Wu; Jian Zhou

doi:10.1002/asia.201300053

A catalyst-free, one-pot three-component aminomethylation of α-substituted nitroacetates: theoretical and experimental studies into the rate-accelerating effects of the solvent methanol

Chem Asian J. 2013 May;8(5):877-82. doi: 10.1002/asia.201300053. Epub 2013 Mar 5.

Authors

Cong-Bin Ji¹, Zhong-Yan Cao, Xin Wang, De-Yin Wu, Jian Zhou

Affiliation

¹ Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai 200062, China.

PMID: 23463603
DOI: 10.1002/asia.201300053

Abstract

3, 2, 1 go! An unprecedented one-pot, catalyst-free, three-component aminomethylation of α-substituted nitroacetates, formalin, and amines has been reported, thereby enabling the highly efficient synthesis of α,β-diamino acid precursors with great structural diversity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetates / chemistry*
Catalysis
Hydrogen Bonding
Imidazolidines / chemical synthesis*
Imidazolidines / chemistry
Magnetic Resonance Spectroscopy
Methanol / chemistry*
Methylation
Models, Molecular
Molecular Structure
Solvents / chemistry

Substances

Acetates
Imidazolidines
Solvents
nitroacetic acid
Methanol