Sterically bulky caging for light-inducible protein activation

Satoshi Takamori; Satoshi Yamaguchi; Noriyuki Ohashi; Teruyuki Nagamune

doi:10.1039/c3cc38026b

Sterically bulky caging for light-inducible protein activation

Chem Commun (Camb). 2013 Apr 14;49(29):3013-5. doi: 10.1039/c3cc38026b.

Authors

Satoshi Takamori¹, Satoshi Yamaguchi, Noriyuki Ohashi, Teruyuki Nagamune

Affiliation

¹ Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Tokyo, 113-8656, Japan.

PMID: 23459684
DOI: 10.1039/c3cc38026b

Abstract

A method for caging a target protein with steric regulator molecules was developed to enable simple, strict, light-induced control of protein activity.

MeSH terms

Biotin / chemistry
Biotin / metabolism
Biotinylation
Light*
Muramidase / chemistry
Muramidase / metabolism
Polyethylene Glycols / chemistry
Proteins / chemistry
Proteins / metabolism*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Streptavidin / chemistry
Streptavidin / metabolism

Substances

Proteins
Polyethylene Glycols
Biotin
Streptavidin
Muramidase