Rare syringyl acylated flavonol glycosides from the aerial parts of Leonurus japonicus Houtt

Molecules. 2013 Mar 4;18(3):2967-77. doi: 10.3390/molecules18032967.

Abstract

Five new syringyl acylated flavonol glycosides, named leonurusoides A (1), B (2), C (3), D (4), and E (5), together with one known one 6 were obtained from the aerial parts of Leonurus japonicus. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, HRESI-TOF-MS, 1D and 2D NMR). Compounds 1-6 showed triglyceride (TG) accumulation inhibitory effects in free fatty acid-induced HepG2 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Flavonols / chemistry*
  • Flavonols / pharmacology
  • Glycosides / chemistry*
  • Glycosides / pharmacology
  • Hep G2 Cells
  • Humans
  • Leonurus / chemistry*
  • Lipid Metabolism / drug effects
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Components, Aerial / chemistry*
  • Plant Extracts / chemistry

Substances

  • Flavonols
  • Glycosides
  • Plant Extracts