Placental histopathological changes associated with Plasmodium vivax infection during pregnancy

PLoS Negl Trop Dis. 2013;7(2):e2071. doi: 10.1371/journal.pntd.0002071. Epub 2013 Feb 14.

Abstract

Histological evidence of Plasmodium in the placenta is indicative of placental malaria, a condition associated with severe outcomes for mother and child. Histological lesions found in placentas from Plasmodium-exposed women include syncytial knotting, syncytial rupture, thickening of the placental barrier, necrosis of villous tissue and intervillositis. These histological changes have been associated with P. falciparum infections, but little is known about the contribution of P. vivax to such changes. We conducted a cross-sectional study with pregnant women at delivery and assigned them to three groups according to their Plasmodium exposure during pregnancy: no Plasmodium exposure (n = 41), P. vivax exposure (n = 59) or P. falciparum exposure (n = 19). We evaluated their placentas for signs of Plasmodium and placental lesions using ten histological parameters: syncytial knotting, syncytial rupture, placental barrier thickness, villi necrosis, intervillous space area, intervillous leucocytes, intervillous mononucleates, intervillous polymorphonucleates, parasitized erythrocytes and hemozoin. Placentas from P. vivax-exposed women showed little evidence of Plasmodium or hemozoin but still exhibited more lesions than placentas from women not exposed to Plasmodium, especially when infections occurred twice or more during pregnancy. In the Brazilian state of Acre, where diagnosis and primary treatment are readily available and placental lesions occur in the absence of detected placental parasites, relying on the presence of Plasmodium in the placenta to evaluate Plasmodium-induced placental pathology is not feasible. Multivariate logistic analysis revealed that syncytial knotting (odds ratio [OR], 4.21, P = 0.045), placental barrier thickness (OR, 25.59, P = 0.021) and mononuclear cells (OR, 4.02, P = 0.046) were increased in placentas from P. vivax-exposed women when compared to women not exposed to Plasmodium during pregnancy. A vivax-score was developed using these three parameters (and not evidence of Plasmodium) that differentiates between placentas from P. vivax-exposed and unexposed women. This score illustrates the importance of adequate management of P. vivax malaria during pregnancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Brazil
  • Cross-Sectional Studies
  • Female
  • Histocytochemistry
  • Humans
  • Malaria, Falciparum / pathology
  • Malaria, Vivax / pathology*
  • Placenta / pathology*
  • Plasmodium vivax / pathogenicity*
  • Pregnancy
  • Pregnancy Complications, Infectious / pathology*
  • Young Adult

Grants and funding

Financial support was provided by Fundação de Apoio à Pesquisa do Estado de São Paulo –FAPESP (Grant n° 2009/53.889-0), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES (Grant n° AUX-PE-PNPD 2751/2010 and 258/2010) and Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq (Grant n° 475771/2009-5). RMS is supported by Universidade Federal do Acre, CAPES and CNPq (scholarship 141946/2012-1), RA is supported by FAPESP (fellowship 2011/20921-8), JGD is supported by CNPq (scholarship 141684/2012-7), VI was supported by CNPq (scholarship PIBIC/6414681), EHA is supported by FAPESP (fellowship 2011/19525-0), SE (Jovem Pesquisador, Grant n° 2009/53256-7), CRFM (Jovem Pesquisador, Grant n° 2009/53.889-0). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.