Signaling by nuclear receptors

Richard Sever; Christopher K Glass

doi:10.1101/cshperspect.a016709

Signaling by nuclear receptors

Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a016709. doi: 10.1101/cshperspect.a016709.

Authors

Richard Sever¹, Christopher K Glass

Affiliation

¹ Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

Abstract

Nuclear receptors are activated by lipid-soluble signals (e.g., steroid hormones) that cross the plasma membrane. Once activated, most function as transcription factors to control gene expression for numerous biological processes.

Publication types

Review

MeSH terms

Humans
Ligands
Models, Biological*
Organ Specificity / physiology*
Protein Processing, Post-Translational / physiology*
Receptors, Cytoplasmic and Nuclear / metabolism*
Receptors, Cytoplasmic and Nuclear / physiology
Signal Transduction / physiology*

Substances

Ligands
Receptors, Cytoplasmic and Nuclear