Abstract
Phytochemicals investigation on rhizomes of Alpinia mutica has afforded five compounds namely 5,6-dehydrokawain (1), flavokawin B (2), pinostrobin (3) and pinocembrin (4) together with β-sitosterol (5). All crude extracts of the plant demonstrated strong cytotoxicity against CEMss (human T4 lymphoblastoid) cancer cells with IC50 values less than 19 μg/mL, while flavokawin B (2) was the most cytotoxic isolate with IC50 value 1.86±0.37 μg/mL. Most of the crude extracts and isolated compounds showed weak activity in antimicrobial and diphenylpicrylhydrazyl (DPPH) radical scavenging activity tests.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Alpinia / chemistry*
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Anti-Infective Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Bacteria / drug effects
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Bacteria / growth & development
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Biphenyl Compounds / chemistry
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Cell Line, Tumor
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Cell Survival / drug effects
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Disk Diffusion Antimicrobial Tests
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Dose-Response Relationship, Drug
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Free Radical Scavengers / pharmacology
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Picrates / chemistry
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plants, Medicinal
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
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Rhizome
Substances
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Anti-Infective Agents
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Antineoplastic Agents, Phytogenic
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Biphenyl Compounds
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Free Radical Scavengers
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Picrates
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Plant Extracts
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1,1-diphenyl-2-picrylhydrazyl