Abstract
Reaction of Bi(O(t)Bu)3 with aspirin (acetylsalicylic acid = aspH) in dry toluene results in the bismuth(III) complex, [Bi(O2C(C6H4)OAc)3]∞ 1 (O2C(C6H4)OAc = asp), minimum inhibitory concentration (MIC) against Helicobacter pylori ≥ 6.25 μg mL(-1), while the inclusion of a stoichiometric equivalent of KO(t)Bu leads to crystals of the bismuthate salt [KBi(O2C(C6H4)OAc)4]∞ 2.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Aspirin / analogs & derivatives*
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Aspirin / chemical synthesis
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Aspirin / chemistry*
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Aspirin / pharmacology
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Bismuth / chemistry*
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Chemistry Techniques, Synthetic
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Coordination Complexes / chemical synthesis*
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology*
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Helicobacter pylori / drug effects*
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Microbial Sensitivity Tests
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Models, Molecular
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Molecular Conformation
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology*
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Coordination Complexes
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Organometallic Compounds
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bismuth(III) acetylsalicylate
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Aspirin
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Bismuth