Veno-occlusive disease following high dose melphalan

Indian J Hematol Blood Transfus. 2012 Mar;28(1):62-3. doi: 10.1007/s12288-011-0100-4. Epub 2011 Aug 18.

Abstract

Hepatic veno-occlusive disease (VOD) is one of the complications following bone marrow transplantation. This complication is uncommon after HDT for autologous SCT (ASCT) in patients with multiple myeloma (MM). Here we report on a 54 years male with MM developed VOD on day 16 of transplant. The Patient was died due to multi-organ failure. The present case suggests that after HDT for ASCT in patients with MM can complicated with VOD.

Keywords: Melphalan; Veno-occlusive disease.