Industrial applications of the Diels-Alder reaction

Angew Chem Int Ed Engl. 2013 Apr 2;52(14):3822-63. doi: 10.1002/anie.201201636. Epub 2013 Feb 27.

Abstract

The Diels-Alder reaction is one of the most popular transformations for organic chemists to generate molecular complexity efficiently. Surprisingly, little is known about its industrial application for the synthesis of pharmacologically active ingredients, agrochemicals, and flavors and fragrances. This Review highlights selected examples, with a focus on large-scale applications (>1 kg) from a process research and development perspective.

Publication types

  • Review

MeSH terms

  • Agrochemicals / chemical synthesis
  • Agrochemicals / chemistry
  • Cosmetics / chemical synthesis
  • Cosmetics / chemistry
  • Cycloaddition Reaction
  • Flavoring Agents / chemical synthesis
  • Flavoring Agents / chemistry
  • Organic Chemicals / chemical synthesis
  • Organic Chemicals / chemistry*
  • Pharmaceutical Preparations / chemical synthesis
  • Pharmaceutical Preparations / chemistry
  • Stereoisomerism

Substances

  • Agrochemicals
  • Cosmetics
  • Flavoring Agents
  • Organic Chemicals
  • Pharmaceutical Preparations