The coming age of complete, accurate, and ubiquitous proteomes

Mol Cell. 2013 Feb 21;49(4):583-90. doi: 10.1016/j.molcel.2013.01.029.

Abstract

High-resolution mass spectrometry (MS)-based proteomics has progressed tremendously over the years. For model organisms like yeast, we can now quantify complete proteomes in just a few hours. Developments discussed in this Perspective will soon enable complete proteome analysis of mammalian cells, as well, with profound impact on biology and biomedicine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cells, Cultured
  • Computational Biology
  • Fungal Proteins / analysis*
  • Fungal Proteins / chemistry
  • Fungal Proteins / isolation & purification
  • Humans
  • Mass Spectrometry
  • Proteome / analysis*
  • Proteome / chemistry
  • Proteome / isolation & purification
  • Proteomics
  • Yeasts / chemistry*

Substances

  • Fungal Proteins
  • Proteome