Bioactive formulations with sugar-derived surfactants: a new approach for photoprotection and controlled release of promethazine

Cécile Bize; Jean-Christophe Garrigues; Jean-Pierre Corbet; Isabelle Rico-Lattes; Muriel Blanzat

doi:10.1002/cphc.201200932

Bioactive formulations with sugar-derived surfactants: a new approach for photoprotection and controlled release of promethazine

Chemphyschem. 2013 Apr 15;14(6):1126-31. doi: 10.1002/cphc.201200932. Epub 2013 Feb 22.

Authors

Cécile Bize¹, Jean-Christophe Garrigues, Jean-Pierre Corbet, Isabelle Rico-Lattes, Muriel Blanzat

Affiliation

¹ Laboratoire IMRCP, UMR CNRS 5623, Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse cedex 9, France.

PMID: 23436492
DOI: 10.1002/cphc.201200932

Abstract

Skin deep: A bioactive formulation for dermal delivery of antihistamines is obtained by using the original properties of catanionic associations towards self-assembly in water. The drug, which participates in its own transport, is preserved from photodegradation when solubilised in the bioactive formulation. The drug release through the skin is also delayed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Allergic Agents / administration & dosage
Drug Carriers / chemistry
Furans / administration & dosage
Humans
Hypersensitivity / drug therapy
Monosaccharides / chemistry*
Promethazine / administration & dosage
Pyridones / administration & dosage
Skin Absorption
Surface-Active Agents / chemistry*

Substances

Anti-Allergic Agents
Drug Carriers
Furans
Monosaccharides
Pyridones
Surface-Active Agents
bolaamphiphile
Promethazine