Antioxidant capacity of two novel bioactive Fe(III)-cyclophane complexes

Molecules. 2013 Jan 29;18(2):1762-74. doi: 10.3390/molecules18021762.

Abstract

The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33-octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe₂PO and Fe₂PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe₂PO and Fe₂PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorption
  • Antioxidants / pharmacology*
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology*
  • Cytoprotection / drug effects
  • Electron Spin Resonance Spectroscopy
  • Electrons
  • Ethers, Cyclic / chemical synthesis
  • Ethers, Cyclic / chemistry
  • Ethers, Cyclic / pharmacology*
  • Humans
  • Hydrogen-Ion Concentration
  • Iron / chemistry
  • Iron / pharmacology*
  • Leukocytes, Mononuclear / drug effects
  • Leukocytes, Mononuclear / metabolism
  • Mass Spectrometry
  • Oxidation-Reduction / drug effects
  • Peroxidase / metabolism
  • Protons
  • Spectrophotometry, Infrared
  • Superoxide Dismutase / metabolism

Substances

  • Antioxidants
  • Coordination Complexes
  • Ethers, Cyclic
  • Protons
  • Iron
  • Peroxidase
  • Superoxide Dismutase