[Determination of molecular genetic markers in acute coronary syndromes and their relationship to cardiovascular adverse events]

Abstract

Introduction: The genes coding for proteins due to their activity in several metabolic pathways could be related with the onset of acute coronary syndromes.

Objective: Relationship among polymorphisms and adverse events in.

Methods: Prospective. In--hospital, one--year follow-up. Inclusion Acute coronary syndromes with ST elevation or depression secondary to atherothrombosis, clinical stability. In all, polymerase chain reaction and length polymorphism of restriction fragments. By standardizing chain reactions and genotyping,a preliminary analysis of distribution of genotypes was performed for each polymorphism and no deviations were observed in the law of Hardy-Weinberg equilibrium (P>.05).

Results: From 2003 to 2005, 150 subjects were enrolled. We analyzed 14 polymorphisms in 9 genes (fibrinogen, factor v, vii, ii, xiii, plasminogen activator and inhibitor-1, C-reactive protein). In acute coronary syndromes, fibrinogen>450 mg/dL and white blood count 8500 cells/mm(3) were markers of poor prognosis to one year. Regression analysis identified the -148 CT/TT and fibrinogen -717 AG/GG of C-reactive protein as a marker of recurrent ischemia and reinfarction 1691GA + AA.

Conclusion: We are showing a relationship among polymorphisms involved in inflammation and hemostasis with adverse events in the acute phase and follow-up in acute coronary syndromes patients that could be considered as markers of ischemic heart disease. Larger sample is needed to confirm these results.