Chronic eosinophilic pneumonia with persistent decreased diffusing capacity for carbon monoxide

BMJ Case Rep. 2013 Feb 15:2013:bcr2012008238. doi: 10.1136/bcr-2012-008238.

Abstract

We report a 15-year-old girl presenting with dry cough, exertional dyspnoea, weight loss, fever and night sweats for over 1 month. Blood tests revealed hypereosinophilia, high IgE and antinuclear antibodies levels. Chest x-rays showed bilateral peripheral infiltrates mostly in the right upper lobe which was confirmed by a chest CT. Bronchoalveolar lavage showed hypercellularity with 28% of eosinophils. Idiopathic chronic eosinophilic pneumonia was confirmed after exclusion of other causes of eosinophilic pneumonia and systemic disease. The patient responded dramatically to oral corticosteroids. Oral corticotherapy was stopped after 4 months. At 8 months of follow-up, diffusing capacity for carbon monoxide (DLCO) remained moderately low (58%) with persistent mild exertional dyspnoea. Cardiopulmonary exercise testing showed muscular peripheral limitation. Even if in our patient, mild exertional dyspnoea can be partly correlated to peripheral deconditioning, DLCO should be systematically evaluated to determine follow-up studies standards, to correlate with subclinical disease, relapse risk and to codify therapeutic options.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Bronchoalveolar Lavage Fluid / cytology
  • Carbon Monoxide*
  • Chronic Disease
  • Diagnosis, Differential
  • Disease Progression
  • Exhalation
  • Female
  • Follow-Up Studies
  • Humans
  • Positron-Emission Tomography
  • Pulmonary Diffusing Capacity / physiology*
  • Pulmonary Eosinophilia / diagnosis*
  • Pulmonary Eosinophilia / metabolism
  • Pulmonary Eosinophilia / physiopathology
  • Respiratory Function Tests
  • Tomography, X-Ray Computed

Substances

  • Carbon Monoxide