Abstract
The synthesis of a novel pharmacophore comprising a DNA-targeted platinum-acridine hybrid agent and estrogen receptor-targeted 4-hydroxy-N-desmethyltamoxifen (endoxifen) using carbamate coupling chemistry and its evaluation in breast cancer cell lines are described.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Acridines / chemistry*
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Antineoplastic Agents, Hormonal / chemistry*
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Antineoplastic Agents, Hormonal / therapeutic use
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Antineoplastic Agents, Hormonal / toxicity
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Breast Neoplasms / drug therapy
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Cell Line, Tumor
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Cell Survival / drug effects
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DNA / chemistry
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DNA / metabolism
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Drug Design*
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Female
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Humans
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Intercalating Agents / chemistry
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Intercalating Agents / therapeutic use
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Intercalating Agents / toxicity
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MCF-7 Cells
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Platinum / chemistry*
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Receptors, Estrogen / antagonists & inhibitors
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Receptors, Estrogen / metabolism
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Tamoxifen / analogs & derivatives*
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Tamoxifen / chemistry
Substances
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Acridines
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Antineoplastic Agents, Hormonal
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Intercalating Agents
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Receptors, Estrogen
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Tamoxifen
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4-hydroxy-N-desmethyltamoxifen
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Platinum
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DNA