Straightforward approach to efficient oxidative DNA cleaving agents based on Cu(II) complexes of heterosubstituted cyclens

Dalton Trans. 2013 Apr 7;42(13):4357-60. doi: 10.1039/c3dt32857k.

Abstract

The Cu(II) complexes of cyclen and two of its heterosubstituted analogues were shown to be efficient oxidative DNA cleavers. The reactivity strongly depends on the heteroatom inserted into the macrocycle (O > S > N).

MeSH terms

  • Coordination Complexes / chemistry*
  • Copper / chemistry*
  • Crystallography, X-Ray
  • Cyclams
  • DNA / chemistry*
  • DNA / metabolism
  • DNA Cleavage
  • Heterocyclic Compounds / chemistry*
  • Molecular Conformation
  • Oxidation-Reduction
  • Plasmids / chemistry
  • Plasmids / metabolism

Substances

  • Coordination Complexes
  • Cyclams
  • Heterocyclic Compounds
  • Copper
  • DNA
  • cyclen