Molecular archeology: unearthing androgen-induced structural rearrangements in prostate cancer genomes

Francesca Demichelis; Levi A Garraway; Mark A Rubin

doi:10.1016/j.ccr.2013.01.019

Molecular archeology: unearthing androgen-induced structural rearrangements in prostate cancer genomes

Cancer Cell. 2013 Feb 11;23(2):133-5. doi: 10.1016/j.ccr.2013.01.019.

Authors

Francesca Demichelis¹, Levi A Garraway, Mark A Rubin

Affiliation

¹ Centre for Integrative Biology, University of Trento, Povo, Trento, 38123, Italy.

Abstract

In this issue of Cancer Cell, Weischenfeldt and colleagues report on the whole genome sequencing of 11 early-onset prostate cancers. Compared to elderly onset prostate cancer, these tumors demonstrate enrichment for androgen-driven structural rearrangements involving ETS family genes. This study confirms observations that prostate cancer manifests discrete genomic subclasses.

Publication types

Comment
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Abstract

Publication types

Grants and funding