Abstract
A library of enriched marine natural product fractions was screened for their antiplasmodial activity using a SYBR green I fluorescence-based assay. Fractions derived from a sponge of the genus Spongosorites exhibited potent inhibition of Plasmodium falciparum growth. This genus of sponge has been reported to contain the nortopsentin and topsentin class of bis-indole imidazole alkaloids. This is the first report of nortopsentin A inhibiting parasite growth at the trophozoite stage at submicromolar 50% inhibitory concentrations (IC(50)).
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Animals
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Antimalarials / isolation & purification
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Antimalarials / pharmacology*
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Erythrocytes / drug effects
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Erythrocytes / parasitology
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Humans
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Imidazoles / isolation & purification
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Imidazoles / pharmacology*
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Indoles / isolation & purification
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Indoles / pharmacology*
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Inhibitory Concentration 50
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Plasmodium falciparum / drug effects*
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Plasmodium falciparum / growth & development
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Porifera / chemistry*
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Small Molecule Libraries / isolation & purification
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Small Molecule Libraries / pharmacology*
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Trophozoites / drug effects*
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Trophozoites / growth & development
Substances
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Alkaloids
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Antimalarials
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Imidazoles
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Indoles
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Small Molecule Libraries
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topsentin A