Detection of carbohydrates on the surface of cancer and normal cells by topography and recognition imaging

Weidong Zhao; Shuheng Liu; Mingjun Cai; Haijiao Xu; Junguang Jiang; Hongda Wang

doi:10.1039/c3cc38885a

Detection of carbohydrates on the surface of cancer and normal cells by topography and recognition imaging

Chem Commun (Camb). 2013 Apr 14;49(29):2980-2. doi: 10.1039/c3cc38885a.

Authors

Weidong Zhao¹, Shuheng Liu, Mingjun Cai, Haijiao Xu, Junguang Jiang, Hongda Wang

Affiliation

¹ State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, PR China.

PMID: 23400247
DOI: 10.1039/c3cc38885a

Abstract

Galactose was detected and localized on the surface of cancer and normal cells by topography and recognition imaging at the single molecular level. There are more galactoses on cancer cells than on normal cells. The stability of galactose-lectin on cancer cells is much lower than that on normal cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dogs
Galactose / analysis*
Galactose / chemistry
HeLa Cells
Humans
Lectins / chemistry
Lectins / metabolism
Madin Darby Canine Kidney Cells
Microscopy, Atomic Force
Neoplasms / metabolism*
Neoplasms / pathology
Phytohemagglutinins / chemistry
Phytohemagglutinins / metabolism
Thermodynamics

Substances

Lectins
Phytohemagglutinins
leukoagglutinins, plants
Galactose