Facile preparation of chiral penicillamine protected gold nanoclusters and their applications in cell imaging

Xuan Yang; Linfeng Gan; Lei Han; Dan Li; Jin Wang; Erkang Wang

doi:10.1039/c3cc00200d

Facile preparation of chiral penicillamine protected gold nanoclusters and their applications in cell imaging

Chem Commun (Camb). 2013 Mar 21;49(23):2302-4. doi: 10.1039/c3cc00200d.

Authors

Xuan Yang¹, Linfeng Gan, Lei Han, Dan Li, Jin Wang, Erkang Wang

Affiliation

¹ State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, PR China.

PMID: 23396404
DOI: 10.1039/c3cc00200d

Abstract

A facile synthesis of chiral penicillamine protected Au nanoclusters with different optical properties has been reported. We have for the first time observed the reversal of CD signals after the scaffolds adsorbed onto the surface of Au NCs. Such Au NCs are utilized for bioimaging due to their low cytotoxicity and stable fluorescence emission.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Cell Survival / drug effects
Gold / chemistry*
HeLa Cells
Humans
Metal Nanoparticles / chemistry*
Metal Nanoparticles / toxicity
Microscopy, Confocal
Penicillamine / chemical synthesis
Penicillamine / chemistry*
Penicillamine / pharmacology
Stereoisomerism

Substances

Gold
Penicillamine