Abstract
In the human genome, 43 different genes are found that encode proteins belonging to the family of the POK (poxvirus and zinc finger and Krüppel)/ZBTB (zinc finger and broad complex, tramtrack, and bric à brac) factors. Generally considered transcriptional repressors, several of these genes play fundamental roles in cell lineage fate decision in various tissues, programming specific tasks throughout the life of the organism. Here, we focus on functions of leukemia/lymphoma-related factor/POK erythroid myeloid ontogenic factor, which is probably one of the most exciting and yet enigmatic members of the POK/ZBTB family.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Cell Differentiation / genetics*
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Cell Lineage / genetics
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Cell Transformation, Neoplastic / genetics
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism
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Hematopoiesis / genetics*
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Humans
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Lymphoma / genetics
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Lymphoma / metabolism
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Lymphoma / pathology
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Models, Genetic
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Transcription Factors / genetics*
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Transcription Factors / metabolism
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Tumor Suppressor Proteins / genetics
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Tumor Suppressor Proteins / metabolism
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Zinc Fingers / genetics
Substances
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DNA-Binding Proteins
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Transcription Factors
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Tumor Suppressor Proteins
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ZBTB7A protein, human