Polymorphism of antigen MPT64 in Mycobacterium tuberculosis strains

Yi Jiang; Haican Liu; Haiyin Wang; Xiangfeng Dou; Xiuqin Zhao; Yun Bai; Li Wan; Guilian Li; Wen Zhang; Chen Chen; Kanglin Wan

doi:10.1128/JCM.02955-12

Polymorphism of antigen MPT64 in Mycobacterium tuberculosis strains

J Clin Microbiol. 2013 May;51(5):1558-62. doi: 10.1128/JCM.02955-12. Epub 2013 Feb 6.

Authors

Yi Jiang¹, Haican Liu, Haiyin Wang, Xiangfeng Dou, Xiuqin Zhao, Yun Bai, Li Wan, Guilian Li, Wen Zhang, Chen Chen, Kanglin Wan

Affiliation

¹ National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention/State Key Laboratory for Infectious Disease Prevention and Control, Beijing, China.

Abstract

We selected 180 clinical isolates of the Mycobacterium tuberculosis complex (MTBC) from patients in China and performed comparative sequence analysis of the mpt64 gene after amplification. From the results, we found that polymorphisms of the mpt64 gene in the MTBC may be the reason for changes in the antigen produced, which may in turn cause alterations of related functions, thereby allowing immune evasion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antigens, Bacterial / chemistry
Antigens, Bacterial / genetics*
Antigens, Bacterial / immunology*
Base Sequence
China
Humans
Immune Evasion
Molecular Sequence Data
Mycobacterium tuberculosis / genetics*
Mycobacterium tuberculosis / immunology*
Mycobacterium tuberculosis / isolation & purification
Nucleic Acid Amplification Techniques
Polymorphism, Single Nucleotide
Protein Structure, Tertiary
Sequence Analysis, DNA
Tuberculosis / microbiology

Substances

Antigens, Bacterial
MPT64 protein, Mycobacterium tuberculosis