Abstract
The yeast Mec1 kinase is a key regulator of the DNA damage response (DDR). In this issue of Genes & Development, Kumar and Burgers (pp. 313-321) report that Ddc1, Dpb11, and Dna2 function in concert to activate Mec1 during S phase of the cell cycle. Furthermore, the Tel1 kinase also contributes to the DDR in S phase when Mec1 activation is compromised.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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DNA Helicases / metabolism*
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Genes, cdc / physiology*
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Intracellular Signaling Peptides and Proteins / metabolism*
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Protein Serine-Threonine Kinases / metabolism*
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Saccharomyces cerevisiae / physiology*
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Saccharomyces cerevisiae Proteins / metabolism*
Substances
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Intracellular Signaling Peptides and Proteins
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Saccharomyces cerevisiae Proteins
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MEC1 protein, S cerevisiae
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Protein Serine-Threonine Kinases
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DNA Helicases
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DNA2 protein, S cerevisiae