Abstract
A new thiazolyl peptide, kocurin (1), was isolated from culture broths of a marine-derived Kocuria palustris. Its structural elucidation was accomplished using a combination of spectroscopic and chemical methods, including HRMS, extensive 1D and 2D NMR analysis, MS/MS fragmentation, and chemical degradation and Marfey's analysis of the resulting amino acid residues. The structure herein reported corrects that previously assigned to PM181104 (3). Kocurin displayed activity against methicillin-resistant Staphylococcus aureus (MRSA), with MIC values in the submicromolar range.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Candida albicans / drug effects
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Gene Expression Regulation, Bacterial / physiology
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Hydrolysis
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Micrococcaceae / chemistry
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Micrococcaceae / metabolism*
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Ozone
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Peptides / chemistry
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Peptides / pharmacology*
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Peptides, Cyclic / chemistry*
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Peptides, Cyclic / pharmacology*
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Protein Conformation
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Thiazoles / chemistry*
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Thiazoles / pharmacology*
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Peptides
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Peptides, Cyclic
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Thiazoles
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kocurin
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Ozone