Iron-catalyzed N-alkylation using π-activated ethers as electrophiles

Org Biomol Chem. 2013 Apr 7;11(13):2147-53. doi: 10.1039/c3ob27128e.

Abstract

A new method for the synthesis of diverse N-alkylation compounds was developed via an iron-catalyzed etheric C(sp(3))-O cleavage with the C-N bond formation in the reaction of π-activated ethers with various nitrogen-based nucleophiles. In addition, the mechanism of this reaction was investigated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Amines / chemical synthesis*
  • Amines / chemistry
  • Catalysis
  • Ethers / chemistry*
  • Ferric Compounds / chemistry*
  • Molecular Structure

Substances

  • Amines
  • Ethers
  • Ferric Compounds