Prediction factors of postoperative hyperbilirubinemia in living right lobe donor: a single-center analysis of 210 cases

Abstract

Background: Hyperbilirubinemia in living liver donor is very common, but the causes are still unclear.

Aims: We sought to clarify the risk factors and predictors of nonobstructive hyperbilirubinemia among living donors.

Methods: We divided 210 consecutive right liver lobe donors into two groups according to the peak total bilirubin postoperatively. We collected data on preoperative, intraoperative, and postoperative biochemical measurements retrospectively, performing multivariate logistic regression analysis adjusting for potential confounders of the risk of hyperbilirubinemia.

Results: There were significant differences between the two groups in donor age, body mass index, operative time, blood loss, macrovescicular steatosis, allogeneic blood transfusion rate, intensive care unit stay, hospital stay and Clavien score after donation (P < .05). Age, graft/donor weight, operative time, and blood loss were significantly associated with the risk of hyperbilirubinemia upon logistic regression analysis.

Conclusion: Hyperbilirubinemia, one type of hepatic dysfunction after a living donor procedure, was associated with multiple independent risk factors.