Visualization of UV-induced damage on single DNA molecules

Chem Commun (Camb). 2013 May 25;49(42):4740-2. doi: 10.1039/c3cc38884k.

Abstract

Ultraviolet radiation induced DNA damage such as double stranded breaks and single stranded breaks is visualized at the level of single DNA molecules. Molecular observations provide a map of DNA radiation-mediated breakages, revealing the sequence dependency of DNA damage rather than random occurrences.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzoxazoles
  • Carbocyanines
  • DNA / metabolism
  • DNA / radiation effects*
  • DNA Breaks*
  • DNA Glycosylases / metabolism
  • Fluorescent Dyes
  • Microscopy, Fluorescence
  • Quinolinium Compounds
  • Ultraviolet Rays / adverse effects*

Substances

  • Alexa Fluor 647
  • Benzoxazoles
  • Carbocyanines
  • Fluorescent Dyes
  • Quinolinium Compounds
  • 1,1'-((4,4,7,7-tetramethyl)-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-oxazole)-2-methylidene)quinolinium
  • DNA
  • DNA Glycosylases
  • deoxyribopyrimidine endonucleosidase