IT (Information Technology) industry is well developed in IC (Integrated Circuit) design, SoC (System-on-a-Chip), embedded, and etc. in Taiwan. Most of the commonly-used platforms are not configurable or modulizable at the moment. The biomedical academia in Taiwan is eager for a flexible biomedical signal sensing platform. This paper presents a novel multi-domain nano-sensor signal processing embedded system. The platform can be tailored for different demands of biomedical signal sensing.