Experimental glucose regulation with a high-order sliding-mode controller

Annu Int Conf IEEE Eng Med Biol Soc. 2012:2012:2056-9. doi: 10.1109/EMBC.2012.6346363.

Abstract

Theoretically High-Order Sliding-Mode Controllers are well suited to perform closed loop glucose regulation because they are insensitive to parameter uncertainties and robust to unknown dynamics that may perturb the system. The implementation of the controller based on the concept of practical relative degree is presented. The controller was tested in Sprague-Dawley rats with steptozotocin induced diabetes. The tests demonstrated high efficacy and robustness of the controller.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / analysis
  • Blood Glucose / metabolism*
  • Computer Simulation
  • Diabetes Mellitus, Experimental / blood*
  • Diabetes Mellitus, Experimental / chemically induced
  • Diabetes Mellitus, Experimental / drug therapy*
  • Drug Therapy, Computer-Assisted / methods*
  • Feedback, Physiological
  • Female
  • Hypoglycemic Agents / administration & dosage
  • Insulin / administration & dosage*
  • Insulin / blood*
  • Models, Biological*
  • Rats
  • Streptozocin
  • Treatment Outcome

Substances

  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin
  • Streptozocin