Abstract
Changes in glycosylation readily occur in cancer and other disease states. Thanks to recent advances in the development of analytical techniques and instrumentation, especially in mass spectrometry, it is now possible to identify blood-derived glycan-based biomarkers using glycomics strategies. This review is an overview of the developments made in the search for glycan-based cancer biomarkers and the technologies currently in use. It is anticipated that the progressing instrumental and bioinformatics developments will allow the identification of relevant glycan biomarkers for the diagnosis, early detection, and monitoring of cancer treatment with sufficient sensitivity and specificity for clinical use.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Antigens, Tumor-Associated, Carbohydrate / blood*
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Antigens, Tumor-Associated, Carbohydrate / chemistry
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Antigens, Tumor-Associated, Carbohydrate / isolation & purification
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Carbohydrate Conformation
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Carbohydrate Sequence
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Glycoproteins / blood*
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Glycoproteins / chemistry
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Glycoproteins / isolation & purification
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Glycosylation
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Humans
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Mass Spectrometry
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Molecular Sequence Data
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Neoplasms / blood
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Neoplasms / diagnosis*
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Polysaccharides / blood
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Polysaccharides / chemistry
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Polysaccharides / isolation & purification
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Prognosis
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Protein Processing, Post-Translational
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Proteome / chemistry
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Proteome / isolation & purification
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Proteome / metabolism
Substances
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Antigens, Tumor-Associated, Carbohydrate
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Glycoproteins
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Polysaccharides
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Proteome