Abstract
There's an APP for that: cell-repellent APP (azido-[polylysine-g-PEG]) is used to create substrates for spatially controlled dynamic cell adhesion. The simple addition of a functional peptide to the culture medium rapidly triggers cell adhesion. This highly accessible yet powerful technique allows diverse applications, demonstrated through tissue motility assays, patterned coculturing and triggered cell shape change.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Azides / chemistry
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Bridged Bicyclo Compounds / chemistry
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Cell Adhesion / drug effects
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Cell Movement / drug effects*
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Cell Shape / drug effects*
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Coated Materials, Biocompatible / chemistry*
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Coated Materials, Biocompatible / pharmacology*
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HeLa Cells
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Humans
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Oligopeptides / chemistry
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Polyethylene Glycols / chemistry
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Polylysine / chemistry
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Surface Properties
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Tissue Engineering
Substances
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Azides
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Bridged Bicyclo Compounds
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Coated Materials, Biocompatible
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Oligopeptides
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bicyclo(6.1.0)nonyne
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Polylysine
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Polyethylene Glycols
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arginyl-glycyl-aspartic acid