Infliximab induces a dysregulated tissue-homing profile on human T-lymphocytes in-vitro: a novel mechanism for paradoxical inflammation?

J Crohns Colitis. 2013 Oct;7(9):765-7. doi: 10.1016/j.crohns.2013.01.001. Epub 2013 Jan 24.
No abstract available

Publication types

  • Letter

MeSH terms

  • Antibodies, Monoclonal / pharmacology*
  • B7 Antigens / metabolism
  • Cells, Cultured
  • Gastrointestinal Agents / pharmacology*
  • Humans
  • Inflammation / chemically induced
  • Infliximab
  • Receptors, CCR4 / metabolism
  • Receptors, CCR7 / metabolism
  • Receptors, Lymphocyte Homing / metabolism*
  • T-Lymphocytes / drug effects*
  • T-Lymphocytes / metabolism*
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors

Substances

  • Antibodies, Monoclonal
  • B7 Antigens
  • CCR4 protein, human
  • CCR7 protein, human
  • Gastrointestinal Agents
  • Receptors, CCR4
  • Receptors, CCR7
  • Receptors, Lymphocyte Homing
  • Tumor Necrosis Factor-alpha
  • Infliximab