New PAH derivatives functionalized by cyclic nitrone framework: synthetic design, anti-proliferative activity and interaction with DNA

Bioorg Med Chem. 2013 Mar 1;21(5):1078-81. doi: 10.1016/j.bmc.2013.01.004. Epub 2013 Jan 11.

Abstract

Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. Incorporation of cyclic nitrone framework into the structure of PAHs was studied with respect to their anti-proliferative activities and interaction with double stranded DNA. Theoretical docking studies and UV titration methods were used for preliminary evaluation of binding of new PAH derivatives to DNA structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • DNA / chemistry
  • DNA / metabolism*
  • Drug Design*
  • HCT116 Cells
  • Humans
  • Intercalating Agents / chemical synthesis
  • Intercalating Agents / chemistry
  • Intercalating Agents / toxicity
  • K562 Cells
  • MCF-7 Cells
  • Molecular Docking Simulation
  • Nitrogen Oxides / chemistry*
  • Nucleic Acid Conformation
  • Polycyclic Aromatic Hydrocarbons / chemical synthesis*
  • Polycyclic Aromatic Hydrocarbons / chemistry
  • Polycyclic Aromatic Hydrocarbons / toxicity
  • Structure-Activity Relationship

Substances

  • Intercalating Agents
  • Nitrogen Oxides
  • Polycyclic Aromatic Hydrocarbons
  • nitrones
  • DNA