Abstract
Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. Incorporation of cyclic nitrone framework into the structure of PAHs was studied with respect to their anti-proliferative activities and interaction with double stranded DNA. Theoretical docking studies and UV titration methods were used for preliminary evaluation of binding of new PAH derivatives to DNA structure.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Binding Sites
-
Cell Line, Tumor
-
Cell Proliferation / drug effects
-
DNA / chemistry
-
DNA / metabolism*
-
Drug Design*
-
HCT116 Cells
-
Humans
-
Intercalating Agents / chemical synthesis
-
Intercalating Agents / chemistry
-
Intercalating Agents / toxicity
-
K562 Cells
-
MCF-7 Cells
-
Molecular Docking Simulation
-
Nitrogen Oxides / chemistry*
-
Nucleic Acid Conformation
-
Polycyclic Aromatic Hydrocarbons / chemical synthesis*
-
Polycyclic Aromatic Hydrocarbons / chemistry
-
Polycyclic Aromatic Hydrocarbons / toxicity
-
Structure-Activity Relationship
Substances
-
Intercalating Agents
-
Nitrogen Oxides
-
Polycyclic Aromatic Hydrocarbons
-
nitrones
-
DNA