Abstract
Phytochemical investigation of the methanolic extract of Croton tonkinensis afforded two known kauranes (1, 2), eight new ent-kauranes (3-10), and 16 known ent-kaurane-type diterpenoids (12-27). In addition, 30 known compounds were identified by comparison of their physical and spectroscopic data with reported data. Among the isolated compounds, ent-18-acetoxykaur-16-en-15-one (20) displayed the most significant inhibition of superoxide anion generation and elastase release.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology*
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Croton / chemistry
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Diterpenes, Kaurane / chemistry
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Diterpenes, Kaurane / isolation & purification*
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Diterpenes, Kaurane / pharmacology*
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Molecular Structure
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Pancreatic Elastase / drug effects
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Pancreatic Elastase / metabolism
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Superoxides / antagonists & inhibitors
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Superoxides / metabolism
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Vietnam
Substances
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Anti-Inflammatory Agents
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Diterpenes, Kaurane
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Superoxides
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Pancreatic Elastase