Two cerebrosides isolated from the seeds of Sterculia lychnophora and their neuroprotective effect

Molecules. 2013 Jan 17;18(1):1181-7. doi: 10.3390/molecules18011181.

Abstract

Two cerebrosides named 1-O-b-D-glucopyranosyl-(2S,3R,4E,8Z)-2-[(2-hydroxyoctadecanoyl)amido]-4,8-octadecadiene-1,3-diol (1) and soya-cerebroside I (2) were isolated from the seeds of Sterculia lychnophora for the first time. Their structures were completely characterized by spectroscopic methods including IR, MS and NMR. Compound 1 exhibited moderate neuroprotective effect against SH-SY5Y cell damage induced by hydrogen peroxide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Cell Survival / drug effects
  • Cerebrosides / chemistry
  • Cerebrosides / isolation & purification
  • Cerebrosides / pharmacology*
  • Drug Evaluation, Preclinical
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacology*
  • Humans
  • Hydrogen Peroxide / pharmacology
  • Molecular Structure
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / isolation & purification
  • Neuroprotective Agents / pharmacology*
  • Oxidants / pharmacology
  • Seeds / chemistry*
  • Sterculia / chemistry*

Substances

  • Cerebrosides
  • Drugs, Chinese Herbal
  • Neuroprotective Agents
  • Oxidants
  • Hydrogen Peroxide