Abstract
Two cerebrosides named 1-O-b-D-glucopyranosyl-(2S,3R,4E,8Z)-2-[(2-hydroxyoctadecanoyl)amido]-4,8-octadecadiene-1,3-diol (1) and soya-cerebroside I (2) were isolated from the seeds of Sterculia lychnophora for the first time. Their structures were completely characterized by spectroscopic methods including IR, MS and NMR. Compound 1 exhibited moderate neuroprotective effect against SH-SY5Y cell damage induced by hydrogen peroxide.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line
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Cell Survival / drug effects
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Cerebrosides / chemistry
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Cerebrosides / isolation & purification
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Cerebrosides / pharmacology*
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Drug Evaluation, Preclinical
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacology*
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Humans
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Hydrogen Peroxide / pharmacology
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Molecular Structure
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / isolation & purification
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Neuroprotective Agents / pharmacology*
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Oxidants / pharmacology
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Seeds / chemistry*
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Sterculia / chemistry*
Substances
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Cerebrosides
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Drugs, Chinese Herbal
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Neuroprotective Agents
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Oxidants
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Hydrogen Peroxide