Very bright europium complexes that stain cellular mitochondria

Chem Commun (Camb). 2013 Feb 25;49(16):1600-2. doi: 10.1039/c2cc35247h.

Abstract

The synthesis, structure and photophysical properties of a series of highly emissive europium complexes is reported. Certain complexes enter mammalian cells by macropinocytosis and stain the mitochondria selectively, allowing observation of the Eu emission in cellulo by time-gated spectral imaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amiloride / pharmacology
  • Androstadienes / pharmacology
  • Animals
  • Europium / analysis*
  • Europium / chemistry*
  • Mice
  • Mitochondria / chemistry*
  • Mitochondria / drug effects
  • Mitochondria / metabolism
  • Models, Molecular
  • Molecular Structure
  • NIH 3T3 Cells
  • Organometallic Compounds / analysis
  • Organometallic Compounds / antagonists & inhibitors
  • Organometallic Compounds / chemistry
  • Temperature
  • Wortmannin

Substances

  • Androstadienes
  • Organometallic Compounds
  • Europium
  • Amiloride
  • Wortmannin