Cardioprotective properties of dimethyl sulfoxide during global ischemia-reperfusion of isolated rat heart

Yu V Dmitriev; S M Minasian; E A Demchenko; M M Galagudza

doi:10.1007/s10517-012-1872-8

Cardioprotective properties of dimethyl sulfoxide during global ischemia-reperfusion of isolated rat heart

Bull Exp Biol Med. 2012 Nov;154(1):47-50. doi: 10.1007/s10517-012-1872-8.

Authors

Yu V Dmitriev¹, S M Minasian, E A Demchenko, M M Galagudza

Affiliation

¹ V. A. Almazov Federal Heart, Blood, and Endocrinology Center, St. Petersburg, Russia. jury.v.dmitriev@gmail.com

PMID: 23330088
DOI: 10.1007/s10517-012-1872-8

Abstract

Cardioprotective properties of dimethyl sulfoxide (DMSO) were studied in the isolated rat heart model. Intraperitoneal administration of DMSO to animals for 3 days before the experiment, but not addition of DMSO to the perfusate, reduced infarction size. Both intraperitoneal and intracoronary administration of DMSO reduced the severity of postischemic left-ventricular dysfunction.

MeSH terms

Animals
Cardiotonic Agents / pharmacology*
Dimethyl Sulfoxide / pharmacology*
Heart / physiopathology
Heart Ventricles / drug effects
Male
Myocardial Contraction
Myocardial Infarction / drug therapy*
Myocardial Reperfusion Injury / drug therapy
Myocardial Reperfusion Injury / physiopathology
Myocardial Reperfusion Injury / prevention & control*
Rats
Rats, Wistar
Ventricular Dysfunction, Left / drug therapy
Ventricular Function, Left / drug effects

Substances

Cardiotonic Agents
Dimethyl Sulfoxide