Abstract
Seven new dibenzocyclooctadiene lignans, marlignans M-S (1-7), four new norlignans, marphenols C-F (8-11), and 21 known compounds (12-32) were isolated from the fruits of Schisandra wilsoniana. The structures of 1-11 were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques and CD experiments. Compounds 1-11 were evaluated for their anti-HIV activities and showed EC(50) values in the range 2.97-6.18 μg/mL and therapeutic index values of 5.33-29.13.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-HIV Agents / chemistry
-
Anti-HIV Agents / isolation & purification*
-
Anti-HIV Agents / pharmacology
-
Cyclooctanes / chemistry
-
Cyclooctanes / isolation & purification*
-
Cyclooctanes / pharmacology
-
Drugs, Chinese Herbal / chemistry
-
Drugs, Chinese Herbal / isolation & purification*
-
Drugs, Chinese Herbal / pharmacology
-
Fruit / chemistry
-
HIV-1 / drug effects
-
Lignans / chemistry
-
Lignans / isolation & purification*
-
Lignans / pharmacology
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Schisandra / chemistry*
Substances
-
Anti-HIV Agents
-
Cyclooctanes
-
Drugs, Chinese Herbal
-
Lignans
-
dibenzocyclooctadiene