A 13 mo old spayed female mixed-breed dog presented in a nonambulatory state that was attributed to severe myoclonus secondary to distemper. The authors hypothesized that mitigating the myoclonus would help the dog become ambulatory and expedite convalescence. They injected the severely affected muscles with botulinum toxin on two separate occasions over a period of 18 days. Those injections reduced the myoclonus, helping the dog become ambulatory and attaining a comfortable, functional state.