New nervogenic acid derivatives from Liparis nervosa

Planta Med. 2013 Mar;79(3-4):281-7. doi: 10.1055/s-0032-1328109. Epub 2013 Jan 15.

Abstract

Ten new nervogenic acid derivatives (1-4, 6-11) and one known compound (5) have been isolated from Liparis nervosa. Their structures were determined using extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 3, 4, 9, 10, and 11 were evaluated for their cytotoxicity against A549, H460, Hela, MCF-7, Caco2, and HepG2 human cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Caco-2 Cells / drug effects
  • Cell Line, Tumor
  • Disaccharides / chemistry
  • Drug Screening Assays, Antitumor
  • HeLa Cells / drug effects
  • Hemiterpenes / chemistry
  • Humans
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Orchidaceae / chemistry*
  • Parabens / chemistry

Substances

  • Antineoplastic Agents, Phytogenic
  • Disaccharides
  • Hemiterpenes
  • Parabens