New monoterpene lactones from Actaea cimicifuga

Planta Med. 2013 Mar;79(3-4):308-11. doi: 10.1055/s-0032-1328127. Epub 2013 Jan 15.

Abstract

Three new monoterpene lactones, cimicifugolides A-C (1-3), along with a known one (4), were identified from the dried rhizome of Actaea cimicifuga L. that was used as traditional Chinese medicine for thousands of years with the Chinese common name of shengma. The structures of the new isolates were established using spectroscopic methods, including NMR, mass, UV, and IR spectra. The inhibition activity of compounds 1, 2, and 4 against pancreatic lipase was evaluated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actaea / chemistry*
  • Drug Evaluation, Preclinical / methods
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Lactones / chemistry*
  • Lactones / isolation & purification
  • Lactones / pharmacology*
  • Lipase / antagonists & inhibitors*
  • Magnetic Resonance Spectroscopy
  • Medicine, Chinese Traditional
  • Molecular Structure
  • Monoterpenes / chemistry*
  • Monoterpenes / isolation & purification
  • Monoterpenes / pharmacology*
  • Plant Roots / chemistry
  • Rhizome / chemistry
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Enzyme Inhibitors
  • Lactones
  • Monoterpenes
  • Lipase