Abstract
Pyrroloquinoxalines have proved to be a very attractive scaffold for medicinal chemist in the recent past. These compounds were extensively studied as bioactive compounds and many of them are known to be biologically and medicinally useful molecules, such as anti-HIV agents, antimalarial agents, antagonist agents, anticancer agents, and PARP-1 inhibitors. Additionally, pyrroloquinoxalines are also important intermediates for the construction of 5-HT3 receptor agonists. In this review the developments in biological activities and synthetic methodologies of pyrroloquinoxalines are discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / pharmacology
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Antimalarials / chemical synthesis*
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Antimalarials / chemistry
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Antimalarials / pharmacology
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / toxicity
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Catalysis
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Cell Survival / drug effects
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HIV-1 / drug effects
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Humans
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Metals / chemistry
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Plasmodium falciparum / drug effects
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Poly(ADP-ribose) Polymerase Inhibitors
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Poly(ADP-ribose) Polymerases / metabolism
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Proto-Oncogene Proteins c-akt / antagonists & inhibitors
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Proto-Oncogene Proteins c-akt / metabolism
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Pyrroles / chemistry*
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Quinoxalines / chemical synthesis
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Quinoxalines / chemistry*
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Quinoxalines / pharmacology
Substances
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Anti-HIV Agents
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Antimalarials
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Antineoplastic Agents
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Metals
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Poly(ADP-ribose) Polymerase Inhibitors
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Pyrroles
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Quinoxalines
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Poly(ADP-ribose) Polymerases
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Proto-Oncogene Proteins c-akt