Cell-penetrating peptides (CPPs) as a vector for the delivery of siRNAs into cells

Mol Biosyst. 2013 May;9(5):855-61. doi: 10.1039/c2mb25467k.

Abstract

"Cell-penetrating peptides (CPPs)" is an inclusive term describing relatively small peptides (6-30 amino acid residues) having membrane translocation activity. Due to their efficacy in cellular internalisation and the accompanying low cytotoxicity, CPPs are regarded as promising vectors for intracellular delivery of various membrane-impermeable bioactive molecules. This review provides an overview of the current approaches and describes the potential of CPP-based siRNA delivery systems, specifically those using arginine-rich CPPs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Arginine / chemistry
  • Arginine / genetics
  • Cell Membrane / chemistry
  • Cell Membrane / metabolism
  • Cell-Penetrating Peptides / chemistry
  • Cell-Penetrating Peptides / genetics*
  • Cell-Penetrating Peptides / metabolism
  • Genetic Vectors / chemistry
  • Genetic Vectors / genetics*
  • Genetic Vectors / metabolism
  • Humans
  • Molecular Sequence Data
  • RNA, Small Interfering / genetics*
  • Reproducibility of Results
  • Transfection / methods*

Substances

  • Cell-Penetrating Peptides
  • RNA, Small Interfering
  • Arginine