1H NMR detection of small molecules in human urine with a deep cavitand synthetic receptor

Daniel A Ryan; Julius Rebek Jr

doi:10.1039/c2an36635e

1H NMR detection of small molecules in human urine with a deep cavitand synthetic receptor

Analyst. 2013 Feb 21;138(4):1008-10. doi: 10.1039/c2an36635e.

Authors

Daniel A Ryan¹, Julius Rebek Jr

Affiliation

¹ The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

PMID: 23304698
DOI: 10.1039/c2an36635e

Abstract

A water-soluble deep cavitand recognized alkylammonium salts, including the drug amantadine hydrochloride, in spiked samples of human urine. The signals of the guests are detected by (1)H NMR upfield of 0 ppm and so occur in a spectroscopic window that is outside of the normal region and distinct from the signals of the biofluid components.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Amantadine / urine*
Ethers, Cyclic / chemistry*
Humans
Hydrogen
Magnetic Resonance Spectroscopy / methods*
Receptors, Artificial / chemistry*
Resorcinols / chemistry*

Substances

Ethers, Cyclic
Receptors, Artificial
Resorcinols
cavitand
Hydrogen
Amantadine