Engineering enzyme stability and resistance to an organic cosolvent by modification of residues in the access tunnel

Angew Chem Int Ed Engl. 2013 Feb 11;52(7):1959-63. doi: 10.1002/anie.201206708. Epub 2013 Jan 9.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocatalysis
  • Dimethyl Sulfoxide / chemistry*
  • Enzyme Stability
  • Enzymes / chemistry
  • Enzymes / metabolism*
  • Evolution, Molecular
  • Kinetics
  • Molecular Dynamics Simulation
  • Protein Engineering
  • Solvents / chemistry*

Substances

  • Enzymes
  • Solvents
  • Dimethyl Sulfoxide