The understanding and classification of academic systems of acupuncture-moxibustion of GAO Wu can be initially clarified through Keynotes of Acupuncture-Moxibustion. On the base of theoretical system of Neijing (Internal Classic) and Nanjing (Classic on Medical Problems), needling manipulations, treatment, meridians and acupoints were taken as the major knowledge models to construct the framework of the academic system by GAO Wu. The "nine needles" and "manipulations" were taken as the starting point of acupuncture. "Reducing and reinforcing methods" were held as the requirement for advanced skills of acupuncturists. Moreover, syndromes based on the theory of was 12 regular meridians was emphasized to combine the theory and clinical practice tightly. Therefore, it is concluded that GAO Wu's classification of acupuncture-moxibustion academic system enlightened and provided experiences for the modern acupuncture education and academic research.