This article examines the issue of cultural competence in qualitative cross-cultural mental health research. Conducting qualitative research on mental health and illness requires the researchers to acquire sensitivity to different cultures and develop the skills of cultural competence. We outline the main aims and steps of implementation when incorporating concepts of cultural competence into a qualitative research study. We present a case scenario from studies on women's depression in 3 ethnic groups (Fars, Kurd and Turk) in the Islamic Republic of Iran. The article presents a brief overview of the Campinha-Bacote model and addresses the 5 major constructs of cultural competence as they were applied in the 3 phases of the research process.